- Original Article
- Long-term follow-up of Fanconi anemia: clinical manifestation and treatment outcome
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Byung Gyu Yoon, Hee Na Kim, Ui Joung Han, Hae In Jang, Dong Kyun Han, Hee Jo Baek, Tai Ju Hwang, Hoon Kook
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Clin Exp Pediatr. 2014;57(3):125-134. Published online March 31, 2014
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Purpose The aim of this study was to characterize Korean patients with Fanconi anemia (FA), which is a rare but very challenging genetic disease. MethodsThe medical records of 12 FA patients diagnosed at Chonnam National University Hospital from 1991 to 2012 were retrospectively reviewed. ResultsThe median age at diagnosis was 6.2 years. All patients showed evidence of marrow failure and one or more... |
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- Selective embolization of the internal iliac arteries for the treatment of intractable hemorrhage in children with malignancies
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Sul Hee Bae, Dong Kyun Han, Hee Jo Baek, Sun Ju Park, Nam Kyu Chang, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2011;54(4):169-175. Published online April 30, 2011
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Purpose Acute internal hemorrhage is an occasionally life-threatening complication in pediatric cancer patients. Many therapeutic approaches have been used to control bleeding with various degrees of success. In this study, we evaluated the efficacy of selective internal iliac artery embolization for controlling acute intractable bleeding in children with malignancies. MethodsWe retrospectively evaluated the cases of 6 children with various malignancies (acute lymphoblastic... |
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- Comparison of total body irradiation-based or non-total body irradiation-based conditioning regimens for allogeneic stem cell transplantation in pediatric leukemia patients
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Sang Jeong Kim, Dong Kyun Han, Hee Jo Baek, Dong Yeon Kim, Taek Keun Nam, Tai Ju Hwang, Hoon Kook
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Clin Exp Pediatr. 2010;53(4):538-547. Published online April 15, 2010
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Purpose : This study aims to compare the outcome of total body irradiation (TBI)- or non-TBI-containing conditioning regimens for leukemia in children.
Methods : We retrospectively evaluated 77 children conditioned with TBI (n=40) or non-TBI (n=37) regimens, transplanted at Chonnam National University Hospital between January 1996 and December 2007. The type of transplantation, disease
status at the time of transplant, conditioning regimen,... |
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- Thrombotic thrombocytopenic purpura with decreased level of ADAMTS-13 activity and increased level of ADAMTS-13 inhibitor in an adolescent
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Eun Mi Yang, Dong Kyun Han, Hee Jo Baek, Young Ok Kim, Myung Geun Shin, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2010;53(3):428-431. Published online March 15, 2010
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Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by endothelial cell damage, resulting in microangiopathic hemolytic anemia, thrombocytopenia, and various degrees of neurological and renal impairment caused by microvascular thrombi. It is rare in children and frequently follows a fatal course. TTP is divided into 2 types: one is inherited and associated with ADAMTS-13 gene mutations and the other... |
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- Case Report
- A case of atypical hemolytic uremic syndrome as an early manifestation of acute lymphoblastic leukemia
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Dong Kyun Han, Hee Jo Baek, Young Kuk Cho, Chan Jong Kim, Myung Geun Shin, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2010;53(2):253-257. Published online February 15, 2010
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Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children younger than 4 years and is characterized by microangiopathic hemolytic anemia, acute renal failure, and thrombocytopenia. HUS associated with diarrheal prodrome is usually caused by Shiga toxin-producing Escherichia coli O157:H7 or by Shigella dysenteriae, which generally has a better outcome. However, atypical cases show a... |
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- Perivascular epithelioid cell tumor (PEComa) of the ascending colon: the implication of IFN-α2b treatment
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Sun Ju Park, Dong Kyun Han, Hee Jo Baek, Sang Young Chung, Jong Hee Nam, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2010;53(11):975-978. Published online November 30, 2010
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A 7-year-old boy presented with hematochezia and abdominal pain. A 3.7-cm-sized mass was identified in the ascending colon by abdominal computed tomography and colonoscopy. The patient underwent surgical resection. Pathological examination revealed a low-grade perivascular epithelioid cell tumor (PEComa). PEComa in the colon is very rare. Only a few cases have been reported so far. An effective treatment method for... |
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- Facial palsy as the presenting symptom of acute myeloid leukemia
in children: Three cases with stem cell transplantatio
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Hee Jo Baek, Dong Kyun Han, Young Ok Kim, Ic Sun Choi, Tai Ju Hwang, Hoon Kook
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Clin Exp Pediatr. 2009;52(6):713-716. Published online June 15, 2009
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Facial palsy as the presenting symptom of leukemia is very rare, especially in acute myeloid leukemia. A review of the medical literature identified reports on 8 children with AML who had facial paralysis as the presenting sign. Whole brain irradiation (WBI) has been applied in most cases. We present the cases of 3 such children. Achieving a remission without WBI,... |
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- A case of mosaic ring chromosome 13 syndrome
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Soo Young Kim, Soo Min O, Mi Jeong Kim, Eun Song Song, Young Ok Kim, Young Youn Choi, Young Jong Woo, Tai Ju Hwang
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Clin Exp Pediatr. 2009;52(2):242-246. Published online February 15, 2009
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The clinical features of ring chromosome 13 include mental and growth retardation, CNS anomalies, facial dysmorphism, cardiac defects, genital malformations, limb anomalies, skeletal deformities and anal malformations. Although many cases of ring chromosome 13 have been reported worldwide, only 6 cases have been reported in Korea, and the latter cases were not mosaic but pure ring chromosome 13. Here we... |
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- A case of subcutaneous paragonimiasis presented with
pleural effusion
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Soo Young Kim, Sun Ju Park, Si Young Bae, Young Kuk Cho, Chan Jong Kim, Young Jong Woo, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 2008;51(7):760-765. Published online July 15, 2008
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Paragonimiasis is a parasitic infection that occurs following the ingestion of infectious Paragonimus metacercariae from crabs or crayfish. Pulmonary paragonimiasis is the most common clinical manifestation of this infection, but several ectopic paragonimiasis cases have also been reported. Among them, cases of subcutaneous paragonimiasis are rare, especially in children. We report a case of subcutaneous paragonimiasis of the right abdominal... |
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- Wilms` tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR) syndrome: Successful treatment of the first case with
bilateral Wilms` tumors in Korea
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Kyung Sun Min, Hee Jo Baek, Dong Kyun Han, Ju Hee You, Tai Ju Hwang, Dong Deuk Kwon, Hoon Kook
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Clin Exp Pediatr. 2008;51(12):1355-1358. Published online December 15, 2008
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Wilms` tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR) syndrome is caused by deletion of chromosome 11p13, including the Wilms` tumor (WT1) and aniridia gene (PAX6) loci. Here, we report the first case of WAGR syndrome in Korea; the patient was a 2-year-old girl with bilateral aniridia from birth who presented with abdominal distention and mental retardation. Cytogenetically, she had... |
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- Congenital hernia of the lung through the azygoesophageal recess
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Young Seok Choi, Young Jun Son, Si Young Bae, Kyung Sun Min, Young Kuk Cho, Woo Yeon Choi, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 2008;51(10):1123-1126. Published online October 15, 2008
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A lung hernia, defined as the protrusion of pulmonary tissue and pleural membranes through a defect in the thoracic wall, is a rare event. It can be congenital or acquired, and cervical, thoracic, or diaphragmatic in location. We report the rare occurrence of a congenital atraumatic lung herniation through the azygoesophageal recess. An 8-month-old male infant, who was born... |
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- Review Article
- Hematopoietic stem cell transplantation : overview for general pediatrician
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Tai Ju Hwang
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Clin Exp Pediatr. 2007;50(7):613-621. Published online July 15, 2007
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Hematopoietic stem cell transplantation (HSCT) has expanded and evolved substantially in the last decades to treat various malignant and nonmalignant diseases. However, the conditioning regimen can lead to transplantation related death by major organ dysfunction, severe infection and bleeding. In the allogeneic setting, graft versus host disease may also develop, making post-transplant management complex. To overcome these problems, new stem... |
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- Original Article
- Frequency and clinical characteristics of prenatally diagnosed congenital hydronephrosis and outcomes of ureteropelvic junction stenosis
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Hyun Soo Kang, June Seung Sung, Sun Hui Kim, Hee Jo Back, Young Ok Kim, Chan Jong Kim, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 2006;49(8):870-874. Published online August 15, 2006
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Purpose : Popular use of fetal ultrasonography has increased to detect congenital hydronephrosis(CH) which is the most common anomaly prenatally detected. We'd like to determine the frequency and clinical characteristics of prenatally diagnosed CH and outcome of ureteropelvic junction stenosis(UPJS).
Methods : The records of births between January 1994 and June 2003 in Chonnam National University Hospital(CNUH), and the records of... |
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- Analysis of causative microorganisms and choice of antibiotics according to the onset of neonatal sepsis
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June Seung Sung, Dong Yeon Kim, Sun Hee Kim, Hyung Suk Byun, Tai Ju Hwang, Young Youn Choi
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Clin Exp Pediatr. 2006;49(6):623-629. Published online June 15, 2006
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Purpose : The mortality rate of neonatal sepsis has been decreased, however, the incidence has not significantly decreased because of increased invasive procedures. This study was designed to make guidelines for choosing antibiotics by analyzing the causative microorganisms and their antibiotics sensitivity test according to the onset of neonatal sepsis.
Methods : One hundred seven cases of culture proven sepsis... |
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- Case Report
- Pyridoxine responsive sideroblastic anemia in a boy with mitral valve prolapse
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June Seung Sung, Ki Hwan Kim, Dong Gyun Han, Mi Jeong Kim, Young Kook Cho, Hae Yul Chung, Hee Jo Baek, Jae Sook Ma, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2006;49(11):1223-1226. Published online November 15, 2006
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Sideroblastic anemia is a rare, heterogeneous group of disorders characterized by hyperferremia, microcytic hypochromic anemia, and bone marrow erythroid hyperplasia with the presence of numerous ringed sideroblasts. We describe herewith the case of a rare coincidence of sideroblastic anemia and mitral valve prolapse with resultant regurgitation in a 2-year-old boy. In addition to the inherent propensity for the development of... |
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- Original Article
- Prevalence and Risk Factors of Vancomycin-Resistant Enterococci (VRE) Colonization in Neonates
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Hwa Yun Lee, Gi Hwan Kim, Jin Su Choi, Sun Hee Kim, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 2005;48(9):946-952. Published online September 15, 2005
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Purpose : Vancomycin-resistant enterococci(VRE) are now nosocomial pathogens in Korea. But little is known about the prevalence of stool colonization with VRE in neonates in Korea. So we studied the prevalence and risk factors of VRE colonization in the Neonatal Intensive Care Unit(NICU).
Methods : From January 2000 to December 2004, the medical records of 294 neonates(127 cases of VRE group... |
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- Neurologic Complications after Hematopoietic Stem Cell Transplantation in Children
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Moon Young Jeong, Young Kuk Cho, So Youn Kim, Young Ok Kim, Chan Jong Kim, Hoon Kook, Young Jong Woo, Tai Ju Hwang
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Clin Exp Pediatr. 2004;47(9):978-985. Published online September 15, 2004
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Purpose : Neurologic complications(NC) after hematopoietic stem cell transplantation(HSCT) are important because of high mortality and severe sequelae. We analyzed the incidence, manifestation and risk factors of NC in 61 children undergoing HSCT.
Methods : We retrospectively analyzed NC in 61 cases(42 male and 19 female, aged one to 16 years) given HSCT between 1996 and 2003 due to hematologic malignacies,... |
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- Case Report
- Isolated Intracranial Granulocytic Sarcoma as a Relapse Following Unrelated Bone Marrow Transplantation for Myelodysplastic Syndrome in a 1 Year-Old Infant
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Kyung Ran Son, Hoon Kook, So Youn Kim, Hee Jo Back, Seok Joo Kim, Ha Young Noh, Mi Jeong Kim, Ic Sun Choi, Shin Jeong, Jong Hee Nam, Tai Ju Hwang
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Clin Exp Pediatr. 2004;47(9):1008-1012. Published online September 15, 2004
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Isolated relapse of myeloid leukemia as a granulocytic sarcoma(GS) following allogeneic bone marrow transplantation(BMT) is very rare manifestation, and usually associated with a poor prognosis. We report a case of isolated intracranial GS in an infant with myelodysplastic syndrome(MDS) following unrelated BMT. A 7 month-old girl was diagnosed with refractory anemia with excess blasts (RAEB). During observation for a couple... |
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- Original Article
- Prevalence and Risk Factors of Candida Sepsis in
Neonatal Intensive Care Unit
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Ic Sun Choi, Suk Hwan Lim, Chang Yee Cho, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 2002;45(7):836-846. Published online July 15, 2002
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Purpose : With the development of neonatal intensive care and the increased use of systemic antibiotics, candida sepsis has become one of the most important causes of neonatal morbidity and mortality. The purpose of this study was to investigate the prevalence rate and its associated risk factors.
Methods : We retrospectively reviewed medical records of 28 cases with candida sepsis who... |
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- Effect of Dexamethasone on Preventing the Laryngeal Edema Following Extubation in Neonates
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Joon Sung Kim, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1998;41(9):1180-1187. Published online September 15, 1998
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Purpose : We performed this study to evaluate the clinical efficacy and safety of dexamethasone in preventing laryngeal edema following exubation.
Methods : We retrospectively reviewed the medical records of 100 neonates who underwent endotracheal intubation and mechanical ventilation. Subjects were divided into two groups; dexamethasone treated(60 cases, dexamethasone group) and non-treated(40 cases, control group). We examined the underlying diseases of... |
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- Effect of Simultaneous Administration of Hepatitis B Vaccine with DPT and Oral Polio Vaccine
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Hyo Geun Ju, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1998;41(4):451-455. Published online April 15, 1998
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Purpose : The universal vaccination against hepatitis B during early infancy is the only effective
way to control hepatitis B infection in highly endemic areas in Korea. The purpose of this study
was to assess the effectiveness of simultaneous hepatitis B vaccination with DPT and oral polio
at 2, 4, 6 months of age in babies of HBs antigen negative mothers.
Methods : One... |
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- Case Report
- Two Cases of Wolman's in Siblings
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Joon Sung Kim, Tai Huyng Cho, Hoon Kook, Seung Hee Choi, Young Youn Choi, Chang Soo Park, Heoung Keun Kang, Dong Kyu Jin, Tai Ju Hwang
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Clin Exp Pediatr. 1998;41(4):529-537. Published online April 15, 1998
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Wolman' disease is a rare autosomal recessive disorder in which a deficiency of lysosomal acid lipase leads to the accumulation of cholesteryl esters and trigycerides in most of the body tissues. Clinically, it is characterized by abdominal distention, hepatosplenomegaly, vomiting, intractable diarrgeam steatorrhea, malabsorption, inanitionm failure to thrive, and bilateral enlargement and calcification of the adrenal glands demonstrated by roentgenographic... |
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- Original Article
- High Dose of Amphotericin B in Intralipid Emulsion-based Delivery System in Immunocompromised Children with Invasive Fungal Infections
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Geun Mo Kim, Hoon Kook, Sung Ho Cho, Ji Yong Park, Young Jong Woo, Tai Ju Hwang
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Clin Exp Pediatr. 1998;41(2):216-223. Published online February 15, 1998
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Purpose : Fungal infections are an important cause of morbidity and mortality in patients with hematologic malignancies. The therapy of choice in documented or suspected invasive fungal infections has been intravenous Amphotericin B(AmB). Adverse effects such as fever, chills, thrombophlebitis, nausea or vomiting are common. A more serious adverse effect is potential renal impairment. As AmB administration mixed with Intralipid(AmB/Intralipid)... |
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- A Clinical Study on BCG Lymphadenitis
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Jin Soo Hwang, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1997;40(5):614-619. Published online May 15, 1997
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Purpose : We studied the incidence and clinical course of BCG lymphadenitis to investigate the BCG related problem.
Subject and Methods: Three hundred and eighty-six infants received BCG vaccine (Pasteur-1173p2) in the Well Baby Clinic, Dept. of Pediatrics, Chonnam University Hospital from May 1993 and April 1994. Among them, twenty three infants developed regional lymphadenitis. We investigated the clinical course... |
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- Subclavian Catheterization in the Pediatric Patients
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Seung Hee Lee, Sung Ho Cho, Keun Mo Kim, Chan Jong Kim, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 1997;40(3):368-374. Published online March 15, 1997
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Purpose : Central venous catheters are used to deliver antibiotics, chemotherapeutic
agents, and parenteral nutrition for a extended period of time as well as to draw
samples in immunocompromised patients to minimize the discomfort with sampling and
the risk of introducing infections. Hickman/Broviac catheters or implantable devices
have been used in pediatric patients. This study is aimed to evaluate the safety and
clinical efficacy of... |
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- Immunophenotypic Analysis of Umbilical Cord Blood Stem Cells
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Won Ho Kang, Tai Ju Hwang, Hoon Kook, Byung Ju Kim
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Clin Exp Pediatr. 1997;40(11):1572-1581. Published online November 15, 1997
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Purpose : Since umbilical cord blood (UCB), which used to be discarded, was found to be a source of
enriched hematopoietic stem and progenitor cells, basic research to elucidate characteristics of UCB
hematopoietic stem cells (HSCs) and its clinical application to bedside transplantation have been
attempted. Moreover, stem cell transplantation (SCT) has expanded its role, not only in hematopoietic
reconstitution, but in cancer therapy,... |
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- Case Report
- Four Cases of Steroid-Induced Lipodystrophy
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Young Hee Kim, Geun Mo Kim, Young-Yun Choi, Jae Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1995;38(6):843-847. Published online June 15, 1995
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Steroid-induced lipodystrophy is preduced by long-acting injectable glucocortiocoids (triamcinolone acetonides) within three weeks after intramuscular injection. It can be caused by inappropriate use of injectable steroids. Although it is recovered spontaneously without medication or plastic surgery, it may lasts for several years. Recently we experienced four cases of steroid-induced lipodystrophy and present a brief review of related literatures. |
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- Original Article
- A Clinical Study on Infants of Diabetic Mothers
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Gyeong Choe, Young Kwon Choi, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 1993;36(10):1407-1416. Published online October 15, 1993
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Thirty one infants of diabetic mothers(IDM) who had been admitted in Neonatal Intensive Care Unit at Chonnam University Hospital from January 1987 to July 1991 were studied for evaluation of their perinatal outcome and prognosis.
The results were as follws;
1) The distribution of diabetic mothers according to modified White뭩 classification was GD & class A in 12 cases (38.7%), B in... |
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- Original Article
- The diagnostic significance of APR score in early detection of neonatal bacterial infection.
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Ki Won Park, Kyeong Choi, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 1991;34(9):1223-1230. Published online September 30, 1991
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An accurate and rapid diagnostic test is essential in the management of bacterial infection in
neonates because they lack specific symptoms and the bacterial infections in neonates tends to have
rapid progression and poor prognosis.
As for the method, APR (acute phase reactants), a score measuring C-reactive protein (CRP), 상racid
glycoprotein (이-AG) and Haptoglobin (Hp) by latex agglutination seems to be one of promising
methods.
In... |
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- Three cases of nonimmune hydrops fetalis.
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Young Youn Choi, Jae Sook Ma, Tai Ju Hwang, Tae Bok Song
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Clin Exp Pediatr. 1991;34(5):691-699. Published online May 31, 1991
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Nonimmune hydrops fetalis is defined as a pathologic and generalized abnormal accumulation of
serous fluid in the entire body tissues and cavities unassociated with erythroblastosis. After the
licensing of Rh Immune Prophylaxis (1968), the incidence of classic erythroblastosis fetalis has
declined dramatically but the proportion of nonimmune types has increased relatively.
With increasing use of ultrasound as a part of routine obstetric care, fetal... |
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- Clinical observation of small for gestational age.
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Young Zong Oh, Cheol Hee Hwang, Young Youn Choi, Young Joung Woo, Tai Ju Hwang
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Clin Exp Pediatr. 1991;34(1):41-48. Published online January 31, 1991
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Small for gestaional age (SGA) is an entity which we have been slow to recognize in both pediatrics
and obstetrics, despite its common occurrence and rather dramatic clinical manifestations. The goal
of this study is to be enable all physicians involved in perinatal medical care focus their attention on
the fact that infants of the same size but very different gestational ages are... |
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- Three cases of Lyphodystophia Centrifugalis Abdominalis Juvenilis.
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Young Soo Chun, Byung Hee Kim, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 1990;33(8):1148-1154. Published online August 31, 1990
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The Lipodystropia centrifugalis abdominalis juvenilis (LCAJ) is a skin disorder characterized by
progressive, centrifugal loss of subcutaneous fat on inguinal and/or axillary region. The lesion has
slightly red border and scaly change on it. But other skin manifestations or other organ involvements
are not the feature of the disease. We have experienced 3 cases of LCAJ. They were 7 years 1 month
old body,... |
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- Blood Pressure Values of Primary, Middle and High School Children in Kwangju.
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Jin Soo Choi, Ki Weon Park, Jae Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1990;33(7):952-958. Published online July 31, 1990
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For the purpose of establishing normal reference values, the author measured blood pressure of 6,
221 school children (male 3,587, female 2,634) in Kwangju area using automatic noninvasive oscil-
lometic method.
Blood pressure increased as age and height increased. Distributions of systolic blood pressures were
101±7 mmHg (Mean±SD) in boys and 102±7mmHg (Mean±SD) in sgirls at age 7 and increased with
a rate of 1,6... |
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- Treatment of Congenital Pulmonary Arteriovenous Fistula with Therapeutic Embolization in a Child.
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Byung Hee Kim, Young Soo Chun, Jin Soo Choi, Jae Sook Ma, Tai Ju Hwang, Jae Kyu Kim
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Clin Exp Pediatr. 1990;33(6):835-841. Published online June 30, 1990
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Congential pulmonary arteriovenous fistula is an uncommon malformation which has an abnormal
connection between the pulmonary capillary bed, in which venous blood in the pulmonary artery is
shunted through the fistula into the pulmonary vein without exposure to alveolar air, enters the left
heart, and results in systemic arterial unsaturation, polycythemia, cyanosis and clubbing.
Death often results from cerebral abscess and rupture of the... |
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- Preventive Effect of Single Dose Vitamin K for the Late Hemorrhagic Disease of Infancy.
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Young Youn Choi, Hwa Il Kwag, Byung Hee Kim, Tai Ju Hwang
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Clin Exp Pediatr. 1990;33(5):606-614. Published online May 31, 1990
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To evaluate the preventive effect of single dose vitamin K for the late hemorrhagic disease of
infancy, hepaplastin test was carried out in 15 breast-fed and 12 formula-fed babies. Vitamin Ki lmg
was injected immediately after the birth intramuscularly and the test was performed the 1st (before
vitamin k administration), 3rd, 7th, 28th days of life and the end of the 2nd and... |
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- Prognosis according to Etiology and Age at Diagnosis in Congenital Hypothyroidism.
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Myoung Sook Nam, Young Jong Oh, Byung Hee Kim, Young Jong Woo, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 1990;33(4):506-513. Published online April 30, 1990
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A retrospective study on patients with congenital hypothyroidism was undertaken. The following
results were obtained from 17 patients, on whom follow up investigations were available.
1) Males outnumbered females. The etiologic classification revealed: thyroid agenesis (64.7%),
dyshormonogenesis (23.5%), and ectopic thyroid (11.8%).
2) In two-thirds of cases the diagnosis were made under 1 year of age, with 23.5% of cases
being diagnoses below 3 month and 41.2%... |
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- Posterior Nasal Swab Culture in Normal Newborns by Feeding Method.
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Young Youn Choi, Tai Ju Hwang, Jae Sook Ma, Kwang Ok Lee, Byung Hee Kim, Young Soo Chung, En Kyeong Bom, Too Yong Yoo
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Clin Exp Pediatr. 1990;33(4):472-480. Published online April 30, 1990
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To evaluate the difference of normal flora between breast and formula-fed newborns, we performed
quantitative posterior nasal swab culture in 21 breast-and 44 formula-fed newborns.
Positive culture rates of total aerobes and total anaerobes were 100% and 98%, respecitively.
Among the aerobes, positive culture rate was 100% in group B streptococcus, 98% in gram negative
bacteria, 86% in staphylococcus aureus, 82% in staphylococcus epidermidis... |
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- A case of Beckwith-Wiedemann Syndrome.
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Jin Soo Choi, Byung Hee Kim, Young Soo Chon, Hwa Il Kwang, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 1990;33(3):367-372. Published online March 31, 1990
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The Beckwith-Wiedemann syndrome (exomphalos-macroglossia-gigantism: E M G Syndrome) is
characterized by the presence of a wide variety of anomalies such as omphalocele, muscular
macroglossia, gigantism, neonatal hypoglycemia, cytomegaly of the adrenal fetal cortex, hyperplasia
of gonadal interstitial cells, and hyperplastic visceromegaly, particularly of pancreas and kidneys.
Other abnormalities may include hemihypertrophy, microcephaly and mental retardation, prominent
occiput, facial flame nevus, neonatal polycythemia, and linear indentations... |
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- Two Cases of Quintuplets.
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Hwa Il Kwag, Kwang Ok Lee, Wan Lee, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 1989;32(5):687-694. Published online May 31, 1989
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The incidence of multiple pregnancies is realtively low in humanbeing than in other species. The
reported incidence of multiple pregnancies is highest among Blacks and East Indians, followed by
North European White, and is lowest among the Mongolian races. Recently, with advent of clomiphen
therapy, multple pregnancies are more freqently encountered.
Multiple pregnancies are frequently associated with highest rate of maternal morbidities and
pregnancy wastages... |
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- A Case of Ectopic ACTH Syndrome Caused by Wilms Tumor.
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Dong Hun Chi, Sang Bong Han, Young Jong Woo, Tai Ju Hwang
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Clin Exp Pediatr. 1988;31(8):1071-1078. Published online August 31, 1988
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We experienced a extremely rare case of ectopic ACTH syndrome caused by Wilms tumor in a 4
year 8 month-old female patient.
We performed specific radiologic and hormonal studies. Diagnosis was confirmed by histologic and
biochemical findings of tumor mass after right nephrectomy.
A brief review of related literature was made. |
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- A Case of Left Atrial Myxoma in Childhood.
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Heu Ran Min, Myoung Hee Kook, Yong Jong Woo, Jae Suk Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1988;31(2):263-270. Published online February 28, 1988
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Cardiac myxomas are rare in children. Because of their rarity and protean clinical manifestations,
diagnosis is difficult but cardiac myxomas recently have generated a great deal of interest because
they represent a potentially curable form of serious heart disease which can be diagnosed easily and
accurately by echocardiography.
We presented a case of left atrial myxoma in a 13-year old girl. The diagnosis was... |
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- A Epidemiologic Study of Malignant Tumors of Children in Chonnam Area.
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Myong Hee Kook, Hys Ran Min, Tai Ju Hwang
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Clin Exp Pediatr. 1988;31(1):78-85. Published online January 31, 1988
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A Total 655 cases of malignant tumors in childhood under 15 years of age who admitted to general
hospitals in Chonnam area during the 10-year period from January 1976 to December 1985 were
analysed.
The frequency of malignant tumors among total pediatric inpatients was 2.64% (1.48〜4.52%) with
tendency to increse year after year. In 1980, the number of population under 15 years of age... |
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- A Clinico-Epidemilological Study of 55 Cases of Chidhood Idiopathic Thrombocytopenic Purpura.
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Won Ho Kang, Myung Hee Kook, Yong Sang Yoo, Jae Suk Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1987;30(11):1207-1212. Published online November 30, 1987
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Fifty-five children with idiopathic thrombocytopenic purpura (ITP) were admitted to the Department of
pediatrics, Chonnam University Hospital during 6 years and 5 months from January 1980 to May 1986.
We Compared clinical pictures and effects of steroids and platelet concentrates on acute and chronic ITP.
No significant sexual predominance was found in total patients with ITP, but also between acute and
chronic types,... |
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- A Case of Glanzmann's Thrombathenia.
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Saeng Gu Cho, Won Ho Kang, Young Youn Choi, Tai Ju Hwang, Dong Wook Ryang, Joo Young Yoo
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Clin Exp Pediatr. 1986;29(6):668-673. Published online June 30, 1986
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The authors experienced a 6-year-old female patient with Glanzmann’s Thrombathenia
and cerebral palsy. She was admitted with epistaxis, gingival bleeding and easy bruisability.
Platelets of patients showed complete absence of aggreration in response to ADP, collagen,
and epinephrine but only first aggregation to ristocetin. After platelet aggregation test,
bone marrow aspiration, and electron micrographic examination, she was proved as... |
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- Results of Treatment in Children with Acute Lymphocytic Leukemia.
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Saeng Gu Cho, Tai Ju Hwang
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Clin Exp Pediatr. 1986;29(12):1343-1351. Published online December 31, 1986
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The clinical findings on the 1st examination in 70 patients who were admitted to the
pediatric department of Chonnam University Hospital from January, 1977 to January, 1985
as well as the results of treatment in 32 patients were analyzed.
The most frequent age at onset was 4-5 years(15 patients). Male patients outnumbered female patients
by 1.6 : 1. A mediastinal mass and... |
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- Case Report
- A Case of Fatal Intracranial Hemmrhage due to Vitamin K Deficiency.
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Yong Sang Yoo, Moon Tae Jeong, Jai Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1986;29(1):108-112. Published online January 31, 1986
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The authors experienced a case of massive spontaneous intracranial hemorrhage in anotherwise
healthy 21-day-old breast fed male infant. There were no evidences of external trauma.
Coagulation studies showed marked prolongation of prothrombin time and partial thromboplastin time.
They were significantly corrected after vitamin K administration without clinical improvsment.
We concluded that vitamin K deficiency was accounted for the pathogenesis of fatal... |
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- A Case of Kocher-Debre-Semelaigne Syndrome.
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Saeng Gu Cho, Song Tae Kim, Young Youn Choi, Tai Ju Hwang
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Clin Exp Pediatr. 1985;28(11):1130-1135. Published online November 30, 1985
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The authors experienced a 9-year-old male patient with Kocher-Decre-Semelaigne syndrome, hypothyroidism with generalized muscular hypertrophy. He was admitted with puffy face, abdominal distension, retarded growth, mental retardation, generalized muscular hypertrophy and hypertonia. Thyroid function test revealed
hypofunction and thyroid gland was not visualized by 99raTc scintiscan. The stigmas of hypothyroidism and the muscular hypertrophy disappeared promptly after synthyroid replacement. Muscular biopsy... |
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- Original Article
- Early Reduction of Serum Amylase Activity in Children with Epidemic Encephalitis.
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Suk Jung Chang, Eui Hyung Kim, Tai Ju Hwang, Chull Sohn
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Clin Exp Pediatr. 1984;27(4):350-357. Published online April 30, 1984
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In 52 children aged form 5 to 13 years who were acutely starving from epidemic encephalitis, authors measured the level of amylase activity, BUN, GOT, GPT, alkaline phosphatase, total protein, albumin, globulin, creatinine in serum and GOT, GPT, amylase activity in CSF. And in another group of 7 children with acute viral hepatitis, GOT, GPT in serum and CSF were... |
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- Serum and Urine Zinc Values in Infectious Diseases.
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Yong Tai Suh, Hwa Young Kim, Jai Sook Mah, Tai Ju Hwang
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Clin Exp Pediatr. 1984;27(3):237-245. Published online March 31, 1984
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Using atomic absorption spectrophotometer, serum-and urine zinc levels of healthy children aging 4.7 to 6.9 years, and of various infectious diseases, including acute viral hepatitis， tuberculosis, salmonellosis, and shigellosis were determined. The mean zinc levels in healthy children were 76±15.2^g/100 ml in serum and 275土 142.4/ug/L in urine respectively. There was no statistical difference attributable to sex. No remarkable changes... |
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- Case Report
- A Case of Congenital Hypoplastic Anemia.
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Young Jong Woo, Jae Sook Ma, Tai Ju Hwang
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Clin Exp Pediatr. 1983;26(2):188-192. Published online February 28, 1983
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Authors have observed a case of congenital hypoplastic anemia in 18 months old male
patient who was diagnosed through the bone marrow aspiration. The liver was enlarged and
the biopsy specimen disclosed iron deposition in the hepatocyte, which was thought to be
resulted from multiple blood transfusion and administration of iron preparation.
A brief review of related literature was made.
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- A Case of Congenital Biliary Atresia associated with Ectopic Pancreatic Tissue.
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Hyung Chun Kim, Tai Ju Hwang, Kyung Yong Huh
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Clin Exp Pediatr. 1980;23(9):737-740. Published online September 15, 1980
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Congenital biliary atresia is the commonest cause of prolonged obstructive jaundice in the neonatal period, and is due to the pathologic closure of a major portion or segment of the biliary tree. The neonate with prolonged obstructive jaundice poses a diagnostic dilemma that may be insoluble by routine clinical and laboratory studies. This applies particularly to the most common entities,... |
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- Original Article
- Effects of the Cyclophosphamide and 6-Mercaptopurine on the RES Function in Rats.
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Tai Ju Hwang, Hyung Chun Kim
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Clin Exp Pediatr. 1980;23(7):521-526. Published online July 15, 1980
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To study the effect of anticancer drugs on the RESFunction, cyclophosphamide and 6-mercaptopurine were intramuscularly injected and evaluated the reticuloendotherial phagocytic activity by the carbon clearence method in rats. Experimental groups were subdivided by the dosage, into the small and large dosage groups, and by the duration of treatment, into the 1, 3, 5 days and 8days (3 days cessation... |
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- Clinical Studies on Purpura in Children.
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Hyo Duck Kim, Tai Ju Hwang, Jung Hi Oh
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Clin Exp Pediatr. 1979;22(11):977-984. Published online November 15, 1979
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The following results were obtained through the clinical review of 182 cases who were admitted with purpuric manifestation at the Pediatric Department of Chonnam National University Hospital during the four-year period, January 1975 through Decemver 1978. 1. The incidence was in the order of leukemia 50 cases(27.5%), sepsis 33 cases(18.1%), meningococcemia 33 cases(18.1%), allergic purpura 29 cases(15.9%), aplastic anemia 19... |
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